Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 5/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27759166 | 0.84 | PARP1 (0.57) | RAB9AMEN1NPC1KMT2ALMNA | |
| SCHEMBL5708210 | 0.80 | PARP1 (0.47) | ADORA3PARP1PARP2PARP3KDM4E | |
| SCHEMBL2264303 | 0.79 | CA12 (0.57) | MAPTRAB9AMEN1NPC1KMT2A | |
| SCHEMBL27892019 | 0.78 | PARP1 (0.65) | PARP1PARP2PARP3 | |
| SCHEMBL2263531 | 0.77 | PARP1 (0.70) | PARP1PARP2PARP3CA12CA1 | |
| SCHEMBL27738223 | 0.77 | PARP1 (0.60) | MAPTRAB9AMEN1NPC1KMT2A | |
| SCHEMBL27738246 | 0.75 | MEN1 (0.46) | MAPTRAB9AMEN1NPC1KMT2A | |
| SCHEMBL27908942 | 0.72 | PARP1 (0.67) | ADORA3ADORA1PARP1PARP2PARP3 | |
| SCHEMBL27759046 | 0.71 | PARP1 (0.40) | RAB9AMEN1NPC1KMT2ALMNA | |
| SCHEMBL27738177 | 0.70 | PARP1 (0.39) | PARP1PARP2PARP3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101415686-B | Amide substituted indazole and benzotriazole derivatives as poly(ADP-ribose)polymerase (PARP) inhibitors | ANGELETTI P IST RICHERCHE BIO | 2013-03-13 | — | — | CN | disclosed |
| CN-101415686-A | Amide substituted indazole and benzotriazole derivatives as poly(ADP-ribose)polymerase (PARP) inhibitors | ANGELETTI P IST RICHERCHE BIO (IT) | 2009-04-22 | — | — | CN | disclosed |