Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.68 |
| ▸ | CDC7 | O00311 | 10/20 | 0.61 |
| ▸ | CDK1 | P06493 | 3/20 | 0.61 |
| ▸ | CDK2 | P24941 | 3/20 | 0.61 |
| ▸ | GSK3B | P49841 | 3/20 | 0.61 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.61 |
| ▸ | PLK4 | O00444 | 2/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.61 |
| ▸ | PRKCG | P05129 | 2/20 | 0.61 |
| ▸ | PRKACA | P17612 | 2/20 | 0.61 |
| ▸ | MARK3 | P27448 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | FRK | P42685 | 2/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.61 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.61 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.61 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28775679 | 0.92 | JAK2 (0.68) | JAK2CDC7CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL27851390 | 0.91 | JAK2 (0.67) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27928062 | 0.90 | JAK2 (0.71) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27851407 | 0.90 | JAK2 (0.84) | JAK2CDC7CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL27938063 | 0.89 | JAK2 (0.82) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL4190268 | 0.89 | JAK2 (0.77) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27759225 | 0.89 | JAK2 (0.68) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27946090 | 0.89 | JAK2 (0.80) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL28779568 | 0.87 | JAK2 (0.70) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL28779569 | 0.87 | JAK2 (0.70) | JAK2CDC7CDK1CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101410387-A | Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene-and furan-derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-04-15 | — | — | CN | claimed |
| CN-101410387-A | Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene-and furan-derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-04-15 | — | — | CN | disclosed |