Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.80 |
| ▸ | CDC7 | O00311 | 9/20 | 0.80 |
| ▸ | CDK1 | P06493 | 4/20 | 0.80 |
| ▸ | CDK2 | P24941 | 4/20 | 0.80 |
| ▸ | GSK3B | P49841 | 4/20 | 0.80 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.80 |
| ▸ | CDK9 | P50750 | 3/20 | 0.80 |
| ▸ | PLK4 | O00444 | 3/20 | 0.80 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.80 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.80 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.80 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.80 |
| ▸ | PRKCG | P05129 | 3/20 | 0.80 |
| ▸ | PRKACA | P17612 | 3/20 | 0.80 |
| ▸ | MARK3 | P27448 | 3/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.80 |
| ▸ | FRK | P42685 | 3/20 | 0.80 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.80 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.80 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27833194 | 0.99 | JAK2 (0.79) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL28779559 | 0.90 | JAK2 (0.64) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL1208545 | 0.89 | JAK2 (1.00) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL28779557 | 0.89 | JAK2 (0.63) | JAK2CDC7CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL1133736 | 0.88 | JAK2 (0.98) | JAK2CDC7CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL27851388 | 0.88 | JAK2 (0.62) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL28779568 | 0.87 | JAK2 (0.70) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27738492 | 0.87 | JAK2 (0.64) | JAK2CDC7CDK1CDK2GSK3B | |
| Hydrochloric Acid SCHEMBL28794392 | 0.86 | JAK2 (0.68) | JAK2CDC7CDK1CDK2GSK3B | |
| SCHEMBL27946090 | 0.86 | JAK2 (0.80) | JAK2CDC7CDK1CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101410387-A | Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene-and furan-derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-04-15 | — | — | CN | claimed |
| CN-102036983-A | Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1h-pyrrole-3-carboxamides | NERVIANO MEDICAL SCIENCES SRL | 2011-04-27 | — | — | CN | disclosed |
| CN-101410387-A | Pyridyl-and pyrimidinyl-substituted pyrrole-, thiophene-and furan-derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2009-04-15 | — | — | CN | disclosed |