⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2775826 | 0.82 | NPSR1 (0.36) | — | |
| SCHEMBL2775705 | 0.77 | GRIA1 (0.33) | — | |
| SCHEMBL2778463 | 0.73 | GRIA2 (0.42) | — | |
| SCHEMBL2774471 | 0.71 | GRIA1 (0.42) | — | |
| SCHEMBL2778011 | 0.70 | NPSR1 (0.30) | — | |
| SCHEMBL2775841 | 0.69 | CHRNA1 (0.32) | — | |
| SCHEMBL2777591 | 0.69 | CYP11B1 (0.30) | — | |
| SCHEMBL2777124 | 0.66 | GRIA1 (0.37) | — | |
| SCHEMBL2777234 | 0.65 | POLB (0.39) | — | |
| SCHEMBL2777718 | 0.65 | GRIA2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2147915-B1 | New cycloalkylated benzothiadiazine derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-09-15 | — | — | EP | disclosed |
| US-7741320-B2 | Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2010-06-22 | — | — | US | disclosed |
| EP-2147915-A1 | New cycloalkylated benzothiadiazine derivatives, method of preparing same and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2010-01-27 | — | — | EP | disclosed |
| US-20100009974-A1 | Cycloalkylated benzothiadiazines, a process for their preparation and pharmaceutical compostions containing them | LES LABORATOIRES SERVIER (FR) | 2010-01-14 | — | — | US | disclosed |