Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 14/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27719387 | 0.81 | TMEM97 (0.60) | APPTMEM97SIGMAR1ACKR3CCR3 | |
| SCHEMBL27719409 | 0.81 | APP (0.51) | APPTMEM97SIGMAR1OPRK1OPRM1 | |
| SCHEMBL4604725 | 0.77 | CHEK1 (0.45) | APPTMEM97SIGMAR1OPRM1CCR3 | |
| SCHEMBL13989615 | 0.77 | CHRM2 (0.44) | SIGMAR1 | |
| SCHEMBL4606143 | 0.73 | GSK3A (0.51) | CCR3 | |
| SCHEMBL14538537 | 0.73 | KMT2A (0.41) | APPTMEM97SIGMAR1ACKR3CCR3 | |
| SCHEMBL4604262 | 0.73 | LCK (0.48) | — | |
| SCHEMBL28943830 | 0.73 | CCR3 (0.43) | APPTMEM97SIGMAR1OPRK1OPRM1 | |
| SCHEMBL18138031 | 0.70 | PARP1 (0.41) | SIGMAR1 | |
| SCHEMBL7763881 | 0.69 | CHEK1 (0.42) | APPTMEM97SIGMAR1ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101296911-A | Arylurea derivatives as modulators of chemokine receptor activity | NOVARTIS AG (CH) | 2008-10-29 | — | — | CN | disclosed |