SCHEMBL27740741

SCHEMBL27740741

CNCC(O)C(c1cccc(F)c1)N1CCN(CCc2ccccc2)c2ccccc21

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 20/20 0.64
SLC6A4 P31645 20/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4719008 0.90 SLC6A2 (0.67) SLC6A2SLC6A4
SCHEMBL4718368 0.90 SLC6A2 (0.67) SLC6A2SLC6A4
Hydrochloric Acid SCHEMBL5485575 0.89 SLC6A2 (0.67) SLC6A2SLC6A4
SCHEMBL4077428 0.79 SLC6A2 (1.00) SLC6A2SLC6A4
SCHEMBL4080890 0.79 SLC6A2 (1.00) SLC6A2SLC6A4
Hydrochloric Acid SCHEMBL4077189 0.78 SLC6A2 (1.00) SLC6A2SLC6A4
SCHEMBL4717012 0.78 SLC6A2 (0.49) SLC6A2SLC6A4
SCHEMBL4410101 0.76 SLC6A2 (0.69) SLC6A2SLC6A4
SCHEMBL4411969 0.76 SLC6A2 (0.69) SLC6A2SLC6A4
Hydrochloric Acid SCHEMBL4077068 0.75 SLC6A2 (0.70) SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101309904-A 1- (1H-indol-1-yl) -3- (methylamino) -1-phenylpropan-2-ol derivatives and related compounds as monoamine reuptake modulators for the treatment of vasomotor symptoms (VMS) WYETH CORP (US) 2008-11-19 CN claimed
CN-101309904-A 1- (1H-indol-1-yl) -3- (methylamino) -1-phenylpropan-2-ol derivatives and related compounds as monoamine reuptake modulators for the treatment of vasomotor symptoms (VMS) WYETH CORP (US) 2008-11-19 CN disclosed