Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.51 |
| ▸ | HAT1 | O14929 | 3/20 | 0.40 |
| ▸ | EP300 | Q09472 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12234694 | 1.00 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11HAT1 | |
| SCHEMBL12234630 | 0.93 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL22641528 | 0.93 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL13086495 | 0.91 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL12234641 | 0.89 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2540321 | 0.87 | MAPK14 (0.62) | MAPK14HAT1EP300 | |
| SCHEMBL12234696 | 0.86 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11HAT1 | |
| SCHEMBL2546291 | 0.85 | MAPK14 (0.81) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL2546288 | 0.85 | MAPK14 (0.81) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14391369 | 0.85 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437799-A | P38MAP kinase inhibitors | CHROMA THERAPEUTICS LTD (GB) | 2009-05-20 | — | — | CN | claimed |
| CN-102942520-A | P38 map kinase inhibitors | CHROMA THERAPEUTICS LTD | 2013-02-27 | — | — | CN | disclosed |
| CN-101437799-A | P38MAP kinase inhibitors | CHROMA THERAPEUTICS LTD (GB) | 2009-05-20 | — | — | CN | disclosed |