Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.48 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 6/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.40 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9243901 | 1.00 | DPP7 (0.48) | DPP7SLC15A1SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL28555278 | 0.94 | GRIK1 (0.47) | DPP7SLC15A1SLC1A2SLC1A1CA1 | |
| SCHEMBL27653809 | 0.92 | GRIK1 (0.49) | DPP7SLC1A2SLC1A1GRIK1GRIK2 | |
| SCHEMBL27956335 | 0.92 | GRIK1 (0.49) | DPP7SLC1A2SLC1A1GRIK1GRIK2 | |
| SCHEMBL4472431 | 0.92 | GRIK1 (0.49) | DPP7SLC1A2SLC1A1GRIK1GRIK2 | |
| SCHEMBL6741861 | 0.92 | GRIK1 (0.49) | DPP7SLC1A2SLC1A1GRIK1GRIK2 | |
| SCHEMBL16200557 | 0.92 | GRIK1 (0.49) | DPP7SLC1A2SLC1A1GRIK1GRIK2 | |
| SCHEMBL28422475 | 0.90 | GRIK1 (0.47) | DPP7SLC1A2SLC1A1GRIK1GRIK2 | |
| SCHEMBL6445484 | 0.89 | DPP7 (0.50) | DPP7SLC15A1SLC1A2SLC1A1SLC1A3 | |
| SCHEMBL21114423 | 0.89 | DPP7 (0.50) | DPP7SLC15A1SLC1A2SLC1A1SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106255689-B | Heteroaryl SYK Inhibitors | 勃林格殷格翰国际有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-110183440-A | Heteroaryl SYK inhibitor | 勃林格殷格翰国际有限公司 | 2019-08-30 | — | — | CN | disclosed |
| CN-108026080-A | Pyrazolyl-substituted heteroaryl compounds and their use as medicaments | 勃林格殷格翰国际有限公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-106255689-A | Heteroaryl syk inhibitors | 勃林格殷格翰国际有限公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-103827090-B | Substituted quinolines and their use as pharmaceuticals | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-04-20 | — | — | CN | disclosed |
| CN-104334553-A | Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments | BOEHRINGER INGELHEIM INT | 2015-02-04 | — | — | CN | disclosed |
| CN-103827090-A | Substituted quinolines and their use as pharmaceuticals | BOEHRINGER INGELHEIM INT | 2014-05-28 | — | — | CN | disclosed |
| CN-101939316-B | Spirocyclic heterocyclic compounds, medicaments containing said compounds, their use and processes for their preparation | BOEHRINGER INGELHEIM INT | 2013-10-02 | — | — | CN | disclosed |
| CN-102822172-A | Substituted naphthyridines and their use as syk kinase inhibitors | BOEHRINGER INGELHEIM INT | 2012-12-12 | — | — | CN | disclosed |
| CN-101939316-A | Spirocyclic heterocyclic compounds, medicaments containing said compounds, their use and processes for their preparation | BOEHRINGER INGELHEIM INT | 2011-01-05 | — | — | CN | disclosed |
| CN-101426505-A | Dihydrothienopyrimidine for treating inflammatory disorders | BOEHRINGER INGELHEIM INT (DE) | 2009-05-06 | — | — | CN | disclosed |