Dimethylformamide

SCHEMBL27744934

CC1(C(=O)O)COC(c2nc(-c3ccc(F)cc3)c(-c3ccnc(NCC#N)n3)[nH]2)OC1.CN(C)C=O

nearest known ligand 0.67

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	MAPK13	O15264	11/20	0.67

▸	MAPK12	P53778	11/20	0.67

▸	MAPK11	Q15759	11/20	0.67

▸	MAPK14	Q16539	11/20	0.67

▸	BRAF	P15056	2/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5772986	0.95	MAPK13 (0.68)	MAPK13MAPK12MAPK11MAPK14BRAF
Dimethylformamide SCHEMBL27744960	0.92	MAPK14 (0.68)	MAPK13MAPK12MAPK11MAPK14
Dimethylformamide SCHEMBL27724381	0.91	MAPK14 (0.67)	MAPK13MAPK12MAPK11MAPK14
Dimethylformamide SCHEMBL27744933	0.91	MAPK14 (0.70)	MAPK13MAPK12MAPK11MAPK14
Dimethylformamide SCHEMBL27744961	0.91	MAPK13 (0.72)	MAPK13MAPK12MAPK11MAPK14
Dimethylformamide SCHEMBL27744964	0.91	MAPK13 (0.66)	MAPK13MAPK12MAPK11MAPK14BRAF
Dimethylformamide SCHEMBL27724165	0.91	MAPK13 (0.66)	MAPK13MAPK12MAPK11MAPK14BRAF
Dimethylformamide SCHEMBL27724141	0.91	MAPK13 (0.81)	MAPK13MAPK12MAPK11MAPK14
SCHEMBL5770519	0.90	MAPK13 (0.81)	MAPK13MAPK12MAPK11MAPK14BRAF
Dimethylformamide SCHEMBL27745088	0.90	MAPK13 (0.65)	MAPK13MAPK12MAPK11MAPK14BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-100443481-C	Imidazolyl-cyclic acetals	RHONE POULENC RORER LTD (GB)	2008-12-17	—	—	CN	disclosed