Sugi Predict

Sugi Predict / Compounds / Dimethylformamide

Dimethylformamide

Dimethylformamide

SCHEMBL27744993

CC1(C(=O)O)COC(c2nc(-c3ccc(F)cc3)c(-c3ccnc(NCc4cccs4)n3)[nH]2)OC1.CN(C)C=O

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 12/20 0.65
▸ MAPK13 O15264 11/20 0.65
▸ MAPK12 P53778 11/20 0.65
▸ MAPK11 Q15759 11/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5771403 0.95 MAPK14 (0.67) MAPK14MAPK13MAPK12MAPK11
Dimethylformamide SCHEMBL27744933 0.90 MAPK14 (0.70) MAPK14MAPK13MAPK12MAPK11
SCHEMBL5771440 0.90 MAPK14 (0.79) MAPK14MAPK13MAPK12MAPK11
Dimethylformamide SCHEMBL27744960 0.90 MAPK14 (0.68) MAPK14MAPK13MAPK12MAPK11
Benzamide SCHEMBL27744985 0.90 MAPK14 (0.62) MAPK14MAPK13MAPK12MAPK11
Dimethylformamide SCHEMBL28773181 0.90 MAPK13 (0.66) MAPK14MAPK13MAPK12MAPK11
Dimethylformamide SCHEMBL27724600 0.89 MAPK13 (0.82) MAPK14MAPK13MAPK12MAPK11
SCHEMBL5771123 0.89 MAPK14 (0.66) MAPK14MAPK13MAPK12MAPK11
Dimethylformamide SCHEMBL27744935 0.88 MAPK14 (0.75) MAPK14MAPK13MAPK12MAPK11
SCHEMBL5768589 0.88 MAPK14 (0.66) MAPK14MAPK13MAPK12MAPK11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100443481-C Imidazolyl-cyclic acetals RHONE POULENC RORER LTD (GB) 2008-12-17 — — CN disclosed