Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666166 | 0.82 | TRPV1 (0.51) | TRPV1ESR1ESR2AKR1B1KDM4E | |
| SCHEMBL1664223 | 0.70 | TRPV1 (0.55) | TRPV1ESR1ESR2KDM4EMAPT | |
| SCHEMBL1664439 | 0.70 | TRPV1 (0.74) | TRPV1ESR1ESR2GAAPOLB | |
| SCHEMBL1665294 | 0.70 | TRPV1 (0.70) | TRPV1ESR1ESR2AKR1B1GAA | |
| SCHEMBL1663409 | 0.70 | TRPV1 (0.69) | TRPV1ESR1ESR2KDM4EMAPT | |
| SCHEMBL1663964 | 0.70 | TRPV1 (0.54) | TRPV1ESR1ESR2AKR1B1GAA | |
| SCHEMBL1663637 | 0.70 | TRPV1 (0.65) | TRPV1ESR1ESR2AKR1B1KDM4E | |
| SCHEMBL1663398 | 0.69 | TRPV1 (0.72) | TRPV1ESR1ESR2KDM4EGAA | |
| SCHEMBL10446158 | 0.69 | TRPV1 (0.72) | TRPV1ESR1ESR2KDM4EMAPT | |
| SCHEMBL1664011 | 0.69 | TRPV1 (0.72) | TRPV1ESR1ESR2AKR1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101356160-A | Trisubstituted quinazolinone derivatives as vanilloid antagonists | JANSSEN PHARMACEUTICA NV (CH) | 2009-01-28 | — | — | CN | disclosed |