Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27880937 | 1.00 | NR1I2 (0.35) | NR1I2GRM5BRD4BRD2ACE | |
| SCHEMBL27749155 | 0.90 | HDAC8 (0.32) | — | |
| SCHEMBL15855776 | 0.79 | NR1I2 (0.39) | NR1I2 | |
| SCHEMBL1190098 | 0.74 | NR1I2 (0.36) | NR1I2GRM5 | |
| SCHEMBL27706681 | 0.71 | RAMP1 (0.34) | ACE | |
| SCHEMBL3196160 | 0.69 | BRD4 (0.35) | GRM5BRD4BRD2ACE | |
| SCHEMBL14655259 | 0.68 | USP2 (0.35) | BRD4BRD2 | |
| SCHEMBL4700582 | 0.68 | USP2 (0.35) | BRD4BRD2 | |
| SCHEMBL14655356 | 0.68 | BRD4 (0.34) | GRM5BRD4BRD2ACE | |
| SCHEMBL30324543 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101454313-A | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2009-06-10 | — | — | CN | disclosed |