Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | IDO1 | P14902 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2687045 | 0.88 | KDM4E (0.64) | KDM4EIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL4092924 | 0.87 | IDO1 (0.58) | KDM4EIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL13203774 | 0.84 | NR4A2 (0.55) | KDM4EIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL2184960 | 0.84 | NR4A2 (0.55) | KDM4EIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7454499 | 0.82 | KDM4E (0.53) | KDM4EIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL820361 | 0.80 | IDO1 (0.61) | KDM4EIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL28836470 | 0.79 | KDM4E (0.66) | KDM4EIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL9275412 | 0.79 | KDM4E (0.74) | KDM4EIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL27429030 | 0.78 | NQO2 (0.42) | KDM4EIDO1KMT2AMEN1ALDH1A1 | |
| SCHEMBL28952690 | 0.78 | KDM4E (0.56) | KDM4EIDO1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101370803-B | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV | 2012-12-12 | — | — | CN | disclosed |
| CN-101370803-A | Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | CN | disclosed |