Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT1A | P50416 | 13/20 | 0.75 |
| ▸ | CPT1B | Q92523 | 11/20 | 0.75 |
| ▸ | CPT2 | P23786 | 7/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL751968 | 0.92 | CPT1A (0.77) | CPT1ACPT1BCPT2NPC1RAB9A | |
| SCHEMBL27731296 | 0.87 | CPT1A (0.75) | CPT1ACPT1BCPT2NPC1RAB9A | |
| SCHEMBL30016367 | 0.86 | CPT1A (1.00) | CPT1ACPT1BCPT2NPC1RAB9A | |
| SCHEMBL751881 | 0.86 | CPT1A (1.00) | CPT1ACPT1BCPT2NPC1RAB9A | |
| SCHEMBL752891 | 0.82 | CPT1A (0.63) | CPT1ACPT1BCPT2KDM4E | |
| SCHEMBL755264 | 0.81 | CPT1A (0.69) | CPT1ACPT1BCPT2NPC1RAB9A | |
| SCHEMBL752547 | 0.78 | CPT1A (0.77) | CPT1ACPT1BCPT2NPC1RAB9A | |
| SCHEMBL27751899 | 0.78 | CPT1A (0.59) | CPT1ACPT1BCPT2MAPTSMN1; SMN2 | |
| SCHEMBL751559 | 0.78 | CPT1A (0.82) | CPT1ACPT1BCPT2 | |
| SCHEMBL751878 | 0.77 | CPT1A (0.80) | CPT1ACPT1BCPT2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379044-B | Heterobicyclic sulfonamide derivatives for the treatment of diabetes | HOFFMANN LA ROCHE | 2012-04-11 | — | — | CN | disclosed |
| CN-101379044-A | Heterobicyclic sulfonamide derivatives for the treatment of diabetes | HOFFMANN LA ROCHE (CH) | 2009-03-04 | — | — | CN | disclosed |