⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10787462 | 0.86 | — | — | |
| SCHEMBL2257854 | 0.85 | — | — | |
| SCHEMBL4857770 | 0.76 | PTGS1 (0.35) | — | |
| SCHEMBL10786985 | 0.76 | — | — | |
| SCHEMBL10782578 | 0.76 | — | — | |
| SCHEMBL14420375 | 0.72 | — | — | |
| SCHEMBL6297475 | 0.70 | — | — | |
| SCHEMBL11512776 | 0.70 | — | — | |
| SCHEMBL27714617 | 0.70 | CA1 (0.31) | — | |
| SCHEMBL10787458 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060009403-A1 | Dna demethylase antisense and chemotherapy combination | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2006-01-12 | — | — | US | claimed |
| EP-1480655-A2 | DNA DEMETHYLASE ANTISENSE AND CHEMOTHERAPY COMBINATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2004-12-01 | — | — | EP | claimed |
| WO-2003074060-A2 | DNA DEMETHYLASE ANTISENSE AND CHEMOTHERAPY COMBINATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2003-09-12 | — | — | WO | claimed |
| US-5691307-A | ANTITUMOR AGENTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-11-25 | — | — | US | claimed |
| EP-0146838-B1 | (ALKYLSULFONYL)METHANESULFONATES AS ANTICANCER AGENTS | Southern Research Institute (US) | 1987-07-22 | — | — | EP | claimed |
| US-20140162966-A1 | NANOPARTICLES FOR DELIVERY OF LIGANDS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2014-06-12 | — | — | US | disclosed |
| US-8188055-B2 | Inactivators of O6-alkylguanine-DNA alkyltransferase | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-05-29 | — | — | US | disclosed |
| US-7825096-B2 | O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-11-02 | — | — | US | disclosed |
| US-20100204172-A1 | INACTIVATORS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-08-12 | — | — | US | disclosed |
| EP-2134715-A2 | O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE INACTIVATORS | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008137207-A2 | INACTIVATORS OF O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2008109735-A2 | O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE INACTIVATORS | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-09-12 | — | — | WO | disclosed |
| EP-0523100-A4 | O?6 -BENZYLATED GUANINE, GUANOSINE AND 2'-DEOXYGUANOSINE COMPOUNDS POSSESSING O?6 -ALKYLGUANINE-DNA ALKYLTRANSFERASE DEPLETING ACTIVITY | US HEALTH (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0523100-A1 | O?6 -BENZYLATED GUANINE, GUANOSINE AND 2'-DEOXYGUANOSINE COMPOUNDS POSSESSING O?6 -ALKYLGUANINE-DNA ALKYLTRANSFERASE DEPLETING ACTIVITY. | US HEALTH (US) | 1993-01-20 | — | — | EP | disclosed |
| US-5091430-A | Increase response to antitumor agents | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1992-02-25 | — | — | US | disclosed |
| WO-1991013898-A1 | O6-BENZYLATED GUANINE, GUANOSINE AND 2'-DEOXYGUANOSINE COMPOUNDS POSSESSING O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE DEPLETING ACTIVITY | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) | 1991-09-19 | — | — | WO | disclosed |
| US-4727174-A | REACTING METHANESULFONYL CHLORIDE, AT LOW TEMPERATURE, WITH TERTIARY AMINE AND ALCOHOL | SOUTHERN RESEARCH INSTITUTE (US) | 1988-02-23 | — | — | US | disclosed |
| EP-0146838-B1 | (ALKYLSULFONYL)METHANESULFONATES AS ANTICANCER AGENTS | Southern Research Institute (US) | 1987-07-22 | — | — | EP | disclosed |
| US-4611074-A | (Alkylsulfonyl)methanesulfonates as anticancer agents | SOUTHERN RESEARCH INSTITUTE (US) | 1986-09-09 | — | — | US | disclosed |
| EP-0146838-A2 | (Alkylsulfonyl)methanesulfonates as anticancer agents | Southern Research Institute (US) | 1985-07-03 | — | — | EP | disclosed |