Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772063 | 0.94 | PPARA (0.43) | SMN1; SMN2NPSR1PPARAMRGPRX4PDGFRA | |
| SCHEMBL2773812 | 0.93 | MRGPRX4 (0.48) | SMN1; SMN2NPSR1PPARAMRGPRX4NR1H4 | |
| SCHEMBL2770719 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2NPSR1PPARAMRGPRX4PDGFRA | |
| SCHEMBL2775204 | 0.87 | MRGPRX4 (0.47) | SMN1; SMN2PPARAMRGPRX4S1PR1S1PR5 | |
| SCHEMBL2771623 | 0.86 | NR1H4 (0.46) | SMN1; SMN2NPSR1PPARAMRGPRX4PDGFRA | |
| SCHEMBL2770433 | 0.84 | MRGPRX4 (0.47) | PPARAMRGPRX4NR1H4NR4A2 | |
| SCHEMBL2775269 | 0.84 | NR1H4 (0.47) | PPARAMRGPRX4NR1H4NR4A2KMT2A | |
| SCHEMBL2773781 | 0.83 | NR1H4 (0.45) | MRGPRX4NR1H4NR4A2RXRARXRB | |
| SCHEMBL498301 | 0.83 | NR1H4 (0.59) | SMN1; SMN2NPSR1PPARAMRGPRX4PDGFRA | |
| SCHEMBL2770618 | 0.83 | NR1H4 (0.58) | SMN1; SMN2NPSR1PPARAMRGPRX4PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |