Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL129265 | 0.82 | MAPT (0.43) | KMT2AGFERHSD17B10SMN1; SMN2NOS1 | |
| SCHEMBL108390 | 0.79 | MAPT (0.50) | KMT2AHSD17B10SMN1; SMN2MAPTRAB9A | |
| SCHEMBL148961 | 0.78 | — | — | |
| SCHEMBL27858618 | 0.77 | HSD17B10 (0.48) | KMT2AGFERHSD17B10SMN1; SMN2NOS1 | |
| Hydrochloric Acid SCHEMBL4139453 | 0.76 | SMN1; SMN2 (0.45) | KMT2AGFERHSD17B10SMN1; SMN2NOS1 | |
| Hydrochloric Acid SCHEMBL4139458 | 0.76 | SMN1; SMN2 (0.45) | KMT2AGFERHSD17B10SMN1; SMN2NOS1 | |
| SCHEMBL929092 | 0.75 | — | — | |
| SCHEMBL128971 | 0.75 | — | — | |
| SCHEMBL11926443 | 0.74 | SOAT1 (0.44) | KMT2AGFERHSD17B10SMN1; SMN2MAPT | |
| SCHEMBL11828770 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101384554-B | Pyridine-2-carboxamide derivatives | HOFFMANN LA ROCHE | 2012-08-08 | — | — | CN | disclosed |
| CN-101384554-A | Pyridine-2-carboxamide derivatives | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | CN | disclosed |