Morpholine

Morpholine

SCHEMBL27754686

C1COCCN1.Cc1ccc(C(=O)Nc2cc(-c3ccc(Cl)s3)ccc2N)cc1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 15/20 0.58
HDAC1 Q13547 14/20 0.58
HDAC3 O15379 10/20 0.58
KCNH2 Q12809 1/20 0.44
HDAC4 P56524 2/20 0.43
HDAC7 Q8WUI4 2/20 0.43
HDAC10 Q969S8 2/20 0.43
HDAC11 Q96DB2 2/20 0.43
HDAC8 Q9BY41 2/20 0.43
HDAC6 Q9UBN7 2/20 0.43
HDAC9 Q9UKV0 2/20 0.43
HDAC5 Q9UQL6 2/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
NPC1 O15118 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C19 P33261 1/20 0.42
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
NCOR2 Q9Y618 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15624636 0.89 HDAC2 (0.58) HDAC2HDAC1HDAC3KCNH2HDAC4
Morpholine SCHEMBL28782633 0.86 HDAC1 (0.46) HDAC2HDAC1HDAC3KCNH2HDAC4
Morpholine SCHEMBL27755154 0.81 HDAC1 (0.61) HDAC2HDAC1HDAC3KCNH2CYP1A2
Morpholine SCHEMBL27754861 0.80 HDAC2 (0.63) HDAC2HDAC1HDAC3KCNH2
SCHEMBL4580675 0.79 HDAC1 (0.58) HDAC2HDAC1HDAC3KCNH2NPC1
SCHEMBL15397932 0.79 HDAC2 (0.56) HDAC2HDAC1HDAC3HDAC4HDAC7
Morpholine SCHEMBL27755041 0.77 HDAC1 (0.62) HDAC2HDAC1HDAC3KCNH2
Morpholine SCHEMBL27775893 0.77 HDAC2 (0.62) HDAC2HDAC1HDAC3KCNH2
SCHEMBL4580520 0.77 HDAC3 (0.58) HDAC2HDAC1HDAC3KCNH2HDAC8
SCHEMBL25213760 0.75 HDAC1 (0.55) HDAC2HDAC1HDAC3HDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101466670-B Inhibitors of histone deacetylase METHYLGENE INC 2013-04-17 CN claimed
CN-101466670-B Inhibitors of histone deacetylase METHYLGENE INC 2013-04-17 CN disclosed
CN-101466670-A Benzamide derivatives as inhibitors of histone deacetylase METHYLGENE INC (CA) 2009-06-24 CN disclosed