Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.69 |
| ▸ | FBP1 | P09467 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CDK1 | P06493 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | SRC | P12931 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236843 | 0.90 | EGFR (0.81) | EGFRERBB2FBP1KDM4EGAK | |
| SCHEMBL27754820 | 0.86 | EGFR (0.76) | EGFRERBB2FBP1KDM4EGAK | |
| SCHEMBL28038543 | 0.86 | EGFR (0.76) | EGFRGAKCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27775596 | 0.86 | EGFR (0.75) | EGFRFBP1ABL1SRCEPHB2 | |
| SCHEMBL5238394 | 0.85 | EGFR (0.74) | EGFRERBB2FBP1KDM4EGAK | |
| SCHEMBL5238507 | 0.84 | EGFR (0.72) | EGFRERBB2FBP1KDM4EGAK | |
| SCHEMBL29444884 | 0.81 | EGFR (1.00) | EGFRERBB2FBP1KDM4EGAK | |
| SCHEMBL9423 | 0.81 | EGFR (1.00) | EGFRERBB2FBP1KDM4EGAK | |
| SCHEMBL30363011 | 0.81 | EGFR (1.00) | EGFRERBB2FBP1KDM4EGAK | |
| SCHEMBL27754788 | 0.81 | ABCG2 (0.72) | EGFRERBB2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101463015-B | Preparation of 5,6,7-trialkoxy-N-aryl substituted-4-amino quinazoline derivative and compound synthesized thereby | UNIV GUIZHOU | 2010-12-08 | — | — | CN | disclosed |
| CN-101463015-A | Preparation of 5,6,7-trialkoxy-N-aryl substituted-4-amino quinazoline derivative and compound synthesized thereby | UNIV GUIZHOU (CN) | 2009-06-24 | — | — | CN | disclosed |