Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.47 |
| ▸ | TUBB | P07437 | 1/20 | 0.47 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.47 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.47 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7756986 | 0.80 | CDK5 (0.71) | MEN1KMT2ACDK5CDK5R1MAPT | |
| SCHEMBL27741434 | 0.79 | MEN1 (0.71) | MEN1KMT2ACDK5CDK5R1MAPT | |
| SCHEMBL1251102 | 0.77 | CDK5 (0.85) | MEN1KMT2ACDK5CDK5R1MAPT | |
| SCHEMBL4477198 | 0.73 | MEN1 (1.00) | MEN1KMT2ACDK5CDK5R1MAPT | |
| SCHEMBL7753399 | 0.73 | MEN1 (0.72) | MEN1KMT2ACDK5CDK5R1MAPT | |
| SCHEMBL4468574 | 0.70 | NPC1 (0.72) | MEN1KMT2ACDK5CDK5R1MAPT | |
| SCHEMBL1250849 | 0.69 | CDK5 (1.00) | MEN1KMT2ACDK5CDK5R1MAPT | |
| SCHEMBL1250778 | 0.69 | CCNA2 (1.00) | MEN1KMT2ACDK5CDK5R1MAPT | |
| SCHEMBL5726296 | 0.69 | CDK5 (0.70) | MEN1KMT2ACDK5CDK5R1MAPT | |
| SCHEMBL7758169 | 0.69 | CCNA2 (0.55) | MEN1KMT2ACDK5CDK5R1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101380319-A | Inhibitors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma | ALCON INC (CH) | 2009-03-11 | — | — | CN | claimed |
| CN-101380319-A | Inhibitors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma | ALCON INC (CH) | 2009-03-11 | — | — | CN | disclosed |