Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.53 |
| ▸ | HTR2C | P28335 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27766203 | 0.88 | HTR2A (0.52) | HTR2AHTR2CSMN1; SMN2RAB9ACHRM1 | |
| SCHEMBL27787833 | 0.85 | HTR2A (0.67) | HTR2AHTR2CSMN1; SMN2RAB9AKCNH2 | |
| SCHEMBL3143852 | 0.83 | HTR2A (0.56) | HTR2AHTR2CSMN1; SMN2RAB9AKCNH2 | |
| SCHEMBL3148091 | 0.83 | HTR2A (0.56) | HTR2AHTR2CSMN1; SMN2RAB9AKCNH2 | |
| SCHEMBL3143861 | 0.83 | HTR2A (0.56) | HTR2AHTR2CSMN1; SMN2RAB9AKCNH2 | |
| SCHEMBL3139433 | 0.82 | HTR2A (0.72) | HTR2AHTR2CSMN1; SMN2RAB9AKCNH2 | |
| SCHEMBL3139447 | 0.82 | HTR2A (0.72) | HTR2AHTR2CSMN1; SMN2RAB9AKCNH2 | |
| SCHEMBL27787836 | 0.74 | HTR2A (0.66) | HTR2AHTR2CSMN1; SMN2RAB9AKCNH2 | |
| SCHEMBL27766310 | 0.73 | POLB (0.51) | HTR2AHTR2CRAB9AKCNH2KMT2A | |
| SCHEMBL3140063 | 0.70 | HTR2A (0.72) | HTR2AHTR2CKCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101611013-A | As 5-HT2APyrazole derivatives of serotonin receptor modulators for the treatment of disorders related thereto | ARENA PHARM INC (US) | 2009-12-23 | — | — | CN | claimed |
| CN-102838546-A | Pyrazole derivatives as modulators of 5-ht2a serotonin receptor useful for treatment of disorders related thereto | ARENA PHARM INC | 2012-12-26 | — | — | CN | disclosed |