Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | KLK7 | P49862 | 2/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 3/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.34 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3945144 | 0.78 | NR1H2 (0.46) | ABCB1KLK7KLK5CETPNR1H2 | |
| SCHEMBL27461844 | 0.75 | PLA2G10 (0.35) | KLK7KLK5L3MBTL1KMT2APLA2G10 | |
| SCHEMBL27767322 | 0.75 | ABCB1 (0.39) | ABCB1KLK7KLK5L3MBTL1BRD4 | |
| SCHEMBL27852998 | 0.73 | ABCB1 (0.39) | ABCB1KLK7L3MBTL1PLA2G10PLA2G5 | |
| SCHEMBL27914285 | 0.71 | CA1 (0.49) | ABCB1NR1H2NR1H3 | |
| SCHEMBL27510237 | 0.70 | CA1 (0.49) | — | |
| SCHEMBL27746410 | 0.70 | TACR1 (0.40) | ABCB1L3MBTL1BRD4MEN1KMT2A | |
| SCHEMBL28474388 | 0.69 | ABCB1 (0.48) | ABCB1L3MBTL1BRD4PSEN1PSEN2 | |
| SCHEMBL1724982 | 0.68 | KLK7 (0.52) | ABCB1KLK7KLK5CETPPLA2G10 | |
| SCHEMBL27914287 | 0.68 | PLA2G10 (0.47) | KLK7KLK5MEN1KMT2APLA2G10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490035-B | Amino-piperidine derivatives as CETP inhibitors | NOVARTIS AG | 2013-02-13 | — | — | CN | disclosed |
| CN-101490035-A | Amino-piperidine derivatives as CETP inhibitors | NOVARTIS AG (CH) | 2009-07-22 | — | — | CN | disclosed |