Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.55 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3599169 | 0.90 | SCN9A (0.55) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL3606143 | 0.89 | SCN9A (0.53) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL3601991 | 0.82 | SCN9A (0.55) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL3593472 | 0.80 | SCN9A (0.78) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL3609902 | 0.80 | SCN9A (0.53) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL3605775 | 0.78 | SCN9A (0.49) | SCN9ATP53MAPT | |
| SCHEMBL3601900 | 0.77 | SCN9A (0.46) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL4044136 | 0.76 | SCN9A (0.48) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL4038607 | 0.75 | SCN9A (0.48) | SCN9ASCN7ASCN5ASCN2ASCN8A | |
| SCHEMBL14221148 | 0.75 | SCN9A (0.61) | SCN9ASCN7ASCN5ASCN2ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101627039-A | Spiro (furo [3, 2-c] pyridine-3-3 ' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain | XENON PHARMACEUTICALS INC | 2010-01-13 | — | — | CN | disclosed |