Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23630273 | 0.95 | CHEK1 (0.46) | CHEK1KCNH2CDK2AP1 | |
| SCHEMBL28781348 | 0.84 | MCHR1 (0.39) | CHEK1MCHR1 | |
| SCHEMBL8835231 | 0.83 | CHEK1 (0.49) | CHEK1MCHR1KCNH2CDK2AP1 | |
| SCHEMBL26983380 | 0.82 | MCHR1 (0.35) | CHEK1MCHR1KCNH2 | |
| SCHEMBL27768305 | 0.81 | CHEK1 (0.62) | CHEK1CDK2AP1 | |
| SCHEMBL8831254 | 0.81 | CHEK1 (0.62) | CHEK1CDK2AP1 | |
| Hydrochloric Acid SCHEMBL27768311 | 0.80 | CHEK1 (0.61) | CHEK1CDK2AP1 | |
| SCHEMBL29012208 | 0.79 | CHEK1 (0.49) | CHEK1MCHR1CDK2AP1 | |
| SCHEMBL8832033 | 0.79 | CHEK1 (0.51) | CHEK1MCHR1CDK2AP1 | |
| SCHEMBL8835672 | 0.78 | CHEK1 (0.54) | CHEK1KCNH2CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101481380-A | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MEDICINE CO LTD (CN) | 2009-07-15 | — | — | CN | claimed |
| CN-101481380-A | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MEDICINE CO LTD (CN) | 2009-07-15 | — | — | CN | disclosed |