Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.68 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29900038 | 1.00 | CHEK1 (0.68) | CHEK1CDK2AP1KCNH2 | |
| SCHEMBL29900120 | 1.00 | CHEK1 (0.68) | CHEK1CDK2AP1KCNH2 | |
| SCHEMBL4343133 | 1.00 | CHEK1 (0.68) | CHEK1CDK2AP1KCNH2 | |
| Hydrochloric Acid SCHEMBL27747351 | 0.99 | CHEK1 (0.67) | CHEK1CDK2AP1KCNH2 | |
| SCHEMBL27768305 | 0.94 | CHEK1 (0.62) | CHEK1CDK2AP1 | |
| SCHEMBL8831254 | 0.94 | CHEK1 (0.62) | CHEK1CDK2AP1 | |
| Hydrochloric Acid SCHEMBL27768311 | 0.94 | CHEK1 (0.61) | CHEK1CDK2AP1 | |
| SCHEMBL29900086 | 0.92 | CHEK1 (0.56) | CHEK1KCNH2 | |
| SCHEMBL4341670 | 0.92 | CHEK1 (0.56) | CHEK1KCNH2 | |
| SCHEMBL8828193 | 0.91 | CHEK1 (0.56) | CHEK1CDK2AP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115038439-A | Combination cancer therapy with CHK inhibitors | 上海华禹生物科技有限公司 | 2022-09-09 | — | — | CN | claimed |
| CN-115038440-A | Combination cancer therapy with CHK inhibitors | 上海华禹生物科技有限公司 | 2022-09-09 | — | — | CN | claimed |
| CN-101481380-B | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MED XINCHANG PHARM | 2012-10-17 | — | — | CN | claimed |
| CN-101481380-A | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MEDICINE CO LTD (CN) | 2009-07-15 | — | — | CN | claimed |
| CN-115038439-A | Combination cancer therapy with CHK inhibitors | 上海华禹生物科技有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-115038440-A | Combination cancer therapy with CHK inhibitors | 上海华禹生物科技有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-101481380-B | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MED XINCHANG PHARM | 2012-10-17 | — | — | CN | disclosed |
| CN-101481380-A | Thiofuran pyridazine compound, preparation thereof, pharmaceutical composition and uses thereof | ZHEJIANG MEDICINE CO LTD (CN) | 2009-07-15 | — | — | CN | disclosed |