Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | XBP1 | P17861 | 1/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.66 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.66 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965139 | 0.86 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTMEN1KMT2AGAA | |
| SCHEMBL30212894 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTMEN1KMT2AGAA | |
| SCHEMBL9429509 | 0.82 | SMN1; SMN2 (0.69) | SMN1; SMN2MAPTMEN1KMT2AGAA | |
| SCHEMBL31236338 | 0.82 | MAPT (0.77) | SMN1; SMN2MAPTMEN1KMT2AGAA | |
| SCHEMBL5142590 | 0.82 | MAPT (0.77) | SMN1; SMN2MAPTMEN1KMT2AGAA | |
| SCHEMBL30977690 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTMEN1KMT2AGAA | |
| SCHEMBL2184782 | 0.81 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTMEN1KMT2AGAA | |
| SCHEMBL15767201 | 0.80 | MEN1 (0.58) | SMN1; SMN2MAPTMEN1KMT2AGAA | |
| SCHEMBL8347078 | 0.80 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPTMEN1KMT2AGAA | |
| SCHEMBL1603669 | 0.80 | SMN1; SMN2 (0.74) | SMN1; SMN2MAPTMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101490040-B | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial | ASTRAZENECA AB | 2013-06-12 | — | — | CN | disclosed |
| CN-101918391-B | Some 2-pyrazinone derivatives and their use in preparing inhibitors of neutrophile elastase | ASTRAZENECA AB | 2013-06-05 | — | — | CN | disclosed |
| CN-101918391-A | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase | ASTRAZENECA AB | 2010-12-15 | — | — | CN | disclosed |
| CN-101490040-A | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial | ASTRAZENECA AB (SE) | 2009-07-22 | — | — | CN | disclosed |