Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.54 |
| ▸ | MAOA | P21397 | 3/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27845543 | 0.88 | MAOB (0.58) | MAOBMAOAFFAR1NPC1ALDH1A1 | |
| SCHEMBL28572292 | 0.83 | MAOB (0.50) | MAOBMAOAFFAR1NPC1ALDH1A1 | |
| SCHEMBL21198816 | 0.79 | MAOB (0.59) | MAOBMAOAFFAR1NPC1ALDH1A1 | |
| SCHEMBL21198815 | 0.79 | MAOB (0.59) | MAOBMAOAFFAR1NPC1ALDH1A1 | |
| SCHEMBL8877619 | 0.78 | MAOB (0.55) | MAOBMAOAFFAR1NPC1ALDH1A1 | |
| SCHEMBL8876136 | 0.78 | MAOB (0.55) | MAOBMAOAFFAR1NPC1ALDH1A1 | |
| SCHEMBL8875180 | 0.78 | MAOB (0.55) | MAOBMAOAFFAR1NPC1ALDH1A1 | |
| SCHEMBL27319522 | 0.77 | HTR2B (0.53) | MAOBMAOAFFAR1NPC1ALDH1A1 | |
| SCHEMBL24239411 | 0.75 | MAOB (0.51) | MAOBMAOAFFAR1NPC1ALDH1A1 | |
| SCHEMBL29052749 | 0.75 | MAOB (0.51) | MAOBMAOAFFAR1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103271906-A | Use of spiro-oxindole compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2013-09-04 | — | — | CN | disclosed |
| CN-101631546-A | Use of spiro-indolone compounds as therapeutic agents | XENON PHARMACEUTICALS INC | 2010-01-20 | — | — | CN | disclosed |