Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2893451 | 0.86 | GRM5 (0.47) | PKMGRM5MEN1NPC1ALDH1A1 | |
| SCHEMBL2893471 | 0.86 | GRM5 (0.47) | PKMGRM5MEN1NPC1ALDH1A1 | |
| SCHEMBL2893177 | 0.86 | GRM5 (0.47) | PKMGRM5MEN1NPC1ALDH1A1 | |
| SCHEMBL14363428 | 0.84 | GRM5 (0.48) | PKMGRM5MEN1NPC1ALDH1A1 | |
| SCHEMBL4051271 | 0.84 | GRM5 (0.48) | PKMGRM5MEN1NPC1ALDH1A1 | |
| SCHEMBL2895174 | 0.83 | GRM5 (0.47) | PKMGRM5MEN1NPC1ALDH1A1 | |
| SCHEMBL2893766 | 0.82 | GRM5 (0.50) | PKMGRM5MEN1NPC1ALDH1A1 | |
| SCHEMBL27840071 | 0.82 | KLKB1 (0.40) | GRM5ALDH1A1LMNA | |
| SCHEMBL2893769 | 0.82 | GRM5 (0.50) | PKMGRM5MEN1NPC1ALDH1A1 | |
| SCHEMBL27770577 | 0.81 | GRM5 (0.46) | PKMGRM5MEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101547916-A | mGluR5 modulators | ASTRAZENECA AB (SE) | 2009-09-30 | — | — | CN | claimed |
| CN-101484455-A | Fused heterocylic compounds and their use as mgglur5 modulators | ASTRAZENECA AB (SE) | 2009-07-15 | — | — | CN | claimed |