Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.77 |
| ▸ | MTOR | P42345 | 20/20 | 0.77 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.61 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27773724 | 0.92 | PIK3CA (0.75) | PIK3CAMTORPIK3CGMAPK14CSNK1G1 | |
| SCHEMBL3987728 | 0.88 | PIK3CA (0.82) | PIK3CAMTORPIK3CG | |
| SCHEMBL3992451 | 0.87 | PIK3CA (1.00) | PIK3CAMTORPIK3CG | |
| SCHEMBL27794840 | 0.85 | MTOR (0.73) | PIK3CAMTORPIK3CG | |
| Acetic Acid SCHEMBL27773570 | 0.84 | MTOR (0.74) | PIK3CAMTORPIK3CGMAPK14CSNK1G1 | |
| SCHEMBL3987061 | 0.84 | MTOR (0.85) | PIK3CAMTORPIK3CGMAPK14CSNK1G1 | |
| SCHEMBL3987963 | 0.84 | MTOR (0.74) | PIK3CAMTORPIK3CG | |
| SCHEMBL27773582 | 0.83 | PIK3CA (0.55) | PIK3CAMTORPIK3CG | |
| SCHEMBL3987958 | 0.82 | PIK3CA (0.73) | PIK3CAMTOR | |
| SCHEMBL4989661 | 0.82 | PIK3CA (0.85) | PIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101675051-A | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors | WYETH CORP | 2010-03-17 | — | — | CN | disclosed |