Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.70 |
| ▸ | EGFR | P00533 | 11/20 | 0.59 |
| ▸ | PDE5A | O76074 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27754788 | 0.88 | ABCG2 (0.72) | ABCG2EGFRPDE5ABRAFABCB1 | |
| SCHEMBL20546988 | 0.83 | EGFR (0.67) | ABCG2EGFRALKGAKSRC | |
| SCHEMBL30353898 | 0.83 | EGFR (0.67) | ABCG2EGFRALKGAKSRC | |
| SCHEMBL5473767 | 0.82 | ABCG2 (1.00) | ABCG2EGFRALKGAKLCK | |
| SCHEMBL27755185 | 0.82 | EGFR (0.67) | EGFRALKBRAFTNNI3KGAK | |
| SCHEMBL27775602 | 0.82 | EGFR (0.67) | EGFRALKBRAFGAKSRC | |
| SCHEMBL27754820 | 0.82 | EGFR (0.76) | ABCG2EGFRMAPTALKGAK | |
| SCHEMBL27775619 | 0.82 | KDR (0.67) | EGFRALDH1A1MAPTALKMEN1 | |
| SCHEMBL28038543 | 0.82 | EGFR (0.76) | EGFRALDH1A1BRAFGAKSRC | |
| Hydrochloric Acid SCHEMBL5478012 | 0.81 | ABCG2 (0.98) | ABCG2EGFRALKGAKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101463015-B | Preparation of 5,6,7-trialkoxy-N-aryl substituted-4-amino quinazoline derivative and compound synthesized thereby | UNIV GUIZHOU | 2010-12-08 | — | — | CN | disclosed |
| CN-101463015-A | Preparation of 5,6,7-trialkoxy-N-aryl substituted-4-amino quinazoline derivative and compound synthesized thereby | UNIV GUIZHOU (CN) | 2009-06-24 | — | — | CN | disclosed |