Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.62 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.51 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 8/20 | 0.47 |
| ▸ | RXRB | P28702 | 7/20 | 0.47 |
| ▸ | RXRG | P48443 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27779252 | 0.89 | MAPK14 (0.60) | MAPK14PTGER1HPGDNR4A2KMT2A | |
| SCHEMBL4475064 | 0.88 | MAPK14 (0.81) | MAPK14PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4480893 | 0.86 | MAPK14 (0.69) | MAPK14HPGDKDM4EMAPT | |
| SCHEMBL4473993 | 0.82 | MAPK14 (0.70) | MAPK14 | |
| SCHEMBL4477627 | 0.80 | MAPK14 (0.67) | MAPK14PTGER1 | |
| SCHEMBL4378793 | 0.80 | MAPK14 (0.56) | MAPK14PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4468353 | 0.80 | MAPK14 (0.64) | MAPK14PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL4379180 | 0.80 | MAPK14 (0.62) | MAPK14 | |
| SCHEMBL4379270 | 0.80 | MAPK14 (0.77) | MAPK14 | |
| SCHEMBL5861929 | 0.79 | MAPK14 (0.73) | MAPK14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101531631-B | Substituted pyridinones as modulators of p38 map kinase | PHARMACIA CORP | 2011-09-28 | — | — | CN | disclosed |
| CN-101531631-A | Substituted pyridinones as modulators of p38 map kinase | PHARMACIA CORP (US) | 2009-09-16 | — | — | CN | disclosed |