Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 5/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | FLT1 | P17948 | 4/20 | 0.43 |
| ▸ | LYN | P07948 | 4/20 | 0.43 |
| ▸ | FYN | P06241 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | FLT4 | P35916 | 3/20 | 0.43 |
| ▸ | BLK | P51451 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4425440 | 0.90 | SYK (0.47) | KITPDGFRASRCLCKFLT1 | |
| SCHEMBL8233709 | 0.83 | KIT (0.49) | KITPDGFRASRCLCKSYK | |
| SCHEMBL28783643 | 0.83 | KIT (0.57) | KITPDGFRASRCLCKFLT1 | |
| SCHEMBL28783703 | 0.82 | KIT (0.67) | KITPDGFRASRCLYNMEN1 | |
| SCHEMBL4419801 | 0.80 | KIT (0.55) | KITPDGFRASRCLCKSYK | |
| SCHEMBL5061396 | 0.79 | KIT (0.54) | KITPDGFRASRCFGFR1MEN1 | |
| SCHEMBL4417045 | 0.76 | KDR (0.53) | KITPDGFRASRCLCKFLT1 | |
| SCHEMBL10043847 | 0.74 | SYK (0.59) | KITSRCLCKFLT1LYN | |
| SCHEMBL5065289 | 0.74 | BRAF (0.66) | PDGFRASRCLCKFYNSYK | |
| SCHEMBL20852497 | 0.73 | KIT (0.51) | KITPDGFRASRCLYNFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101553232-A | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-10-07 | — | — | CN | claimed |
| CN-101553232-A | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS LLC (US) | 2009-10-07 | — | — | CN | disclosed |