Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.40 |
| ▸ | HPD | P32754 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376565 | 0.84 | MAPK14 (0.54) | MAPK14PTGER1 | |
| SCHEMBL4376528 | 0.82 | MAPK14 (0.50) | MAPK14MRGPRX4 | |
| SCHEMBL27602872 | 0.80 | MAPK14 (0.52) | MAPK14PTGER1 | |
| SCHEMBL4381707 | 0.79 | MAPK14 (0.77) | MAPK14 | |
| SCHEMBL4375353 | 0.76 | MAPK14 (0.60) | MAPK14 | |
| SCHEMBL4376977 | 0.76 | MAPK14 (0.61) | MAPK14PTGER1 | |
| Trifluoroacetic Acid SCHEMBL4467108 | 0.75 | MAPK14 (0.45) | MAPK14PTGER1 | |
| SCHEMBL4387214 | 0.75 | MAPK14 (0.50) | MAPK14PTGER1 | |
| SCHEMBL4379524 | 0.74 | MAPK14 (0.56) | MAPK14 | |
| SCHEMBL4473241 | 0.74 | MAPK14 (0.45) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101531631-B | Substituted pyridinones as modulators of p38 map kinase | PHARMACIA CORP | 2011-09-28 | — | — | CN | disclosed |
| CN-101531631-A | Substituted pyridinones as modulators of p38 map kinase | PHARMACIA CORP (US) | 2009-09-16 | — | — | CN | disclosed |