Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.66 |
| ▸ | APP | P05067 | 2/20 | 0.58 |
| ▸ | CTSD | P07339 | 1/20 | 0.58 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27779712 | 0.93 | BACE1 (0.65) | BACE1APPCTSDBACE2 | |
| SCHEMBL27801194 | 0.92 | BACE1 (0.78) | BACE1APPCTSDBACE2 | |
| SCHEMBL27801193 | 0.92 | BACE1 (0.78) | BACE1APPCTSDBACE2 | |
| SCHEMBL27780184 | 0.92 | BACE1 (0.78) | BACE1APPCTSDBACE2 | |
| SCHEMBL4308389 | 0.90 | BACE1 (0.73) | BACE1APPCTSDBACE2 | |
| SCHEMBL4311460 | 0.89 | BACE1 (0.67) | BACE1APPCTSDBACE2 | |
| SCHEMBL27779787 | 0.88 | BACE1 (0.69) | BACE1APPCTSDBACE2 | |
| SCHEMBL27780060 | 0.88 | BACE1 (0.69) | BACE1APPCTSDBACE2 | |
| SCHEMBL27780186 | 0.86 | BACE1 (0.76) | BACE1APPCTSDBACE2 | |
| SCHEMBL27779711 | 0.86 | BACE1 (0.76) | BACE1APPCTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101641335-A | Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5- phenylimidazolone compounds as ss-secretase inhibitors | WYETH CORP US | 2010-02-03 | — | — | CN | claimed |
| CN-101641335-A | Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5- phenylimidazolone compounds as ss-secretase inhibitors | WYETH CORP US | 2010-02-03 | — | — | CN | disclosed |