Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.56 |
| ▸ | BTK | Q06187 | 5/20 | 0.56 |
| ▸ | PIP4K2A | P48426 | 4/20 | 0.51 |
| ▸ | PIP4K2B | P78356 | 4/20 | 0.51 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.47 |
| ▸ | S100A10 | P60903 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778207 | 1.00 | EGFR (0.56) | EGFRBTKPIP4K2APIP4K2BANXA2 | |
| SCHEMBL2204660 | 0.93 | EGFR (0.56) | EGFRBTKPIP4K2APIP4K2BANXA2 | |
| SCHEMBL691213 | 0.88 | EGFR (0.57) | EGFRBTKPIP4K2APIP4K2BANXA2 | |
| SCHEMBL692000 | 0.88 | EGFR (0.52) | EGFRBTKPIP4K2APIP4K2BANXA2 | |
| SCHEMBL691999 | 0.88 | EGFR (0.52) | EGFRBTKPIP4K2APIP4K2BANXA2 | |
| SCHEMBL12310629 | 0.81 | PIP4K2A (0.60) | EGFRBTKPIP4K2APIP4K2BERBB2 | |
| SCHEMBL690637 | 0.80 | PIP4K2A (0.59) | EGFRBTKPIP4K2APIP4K2BERBB2 | |
| SCHEMBL13883499 | 0.80 | PIP4K2A (0.59) | EGFRBTKPIP4K2APIP4K2BERBB2 | |
| SCHEMBL690638 | 0.80 | PIP4K2A (0.59) | EGFRBTKPIP4K2APIP4K2BERBB2 | |
| SCHEMBL690942 | 0.79 | PIP4K2A (0.76) | EGFRBTKPIP4K2APIP4K2BERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214486-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | Avila Therapeutics, Inc. (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009051822-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2009-04-23 | — | — | WO | disclosed |