Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 5/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 5/20 | 0.41 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27804369 | 0.91 | AAK1 (0.42) | AAK1AXLPAK1BRD4PKN1 | |
| SCHEMBL10263401 | 0.86 | AAK1 (0.49) | AAK1AXLPAK1NEK1CYP3A4 | |
| SCHEMBL27782909 | 0.86 | AAK1 (0.44) | AAK1AXLPAK1NEK1CYP3A4 | |
| SCHEMBL858062 | 0.86 | AXL (0.56) | AAK1AXLPAK1NEK1CYP3A4 | |
| SCHEMBL857911 | 0.83 | KIT (0.52) | AAK1AXLPAK1NTRK1DYRK1A | |
| SCHEMBL858780 | 0.80 | BRD4 (0.51) | AAK1AXLPAK1NEK1NTRK1 | |
| SCHEMBL4301666 | 0.79 | PIK3CA (0.51) | AXLPAK1NTRK1ITKDYRK1A | |
| SCHEMBL859107 | 0.78 | AXL (0.45) | AAK1AXLPAK1NEK1CDC7 | |
| SCHEMBL1364902 | 0.78 | AXL (0.45) | AAK1AXLPAK1NEK1CDC7 | |
| SCHEMBL857852 | 0.78 | MAP3K11 (0.49) | AAK1AXLPAK1CDC7PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1925855-B | Compounds and methods for development of Ret modulators | PLEXXIKON INC | 2010-06-16 | — | — | CN | claimed |