Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | SCN4A | P35499 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30056467 | 1.00 | EGFR (0.55) | EGFRBACE1PIK3CDPIK3CAKDM4E | |
| SCHEMBL28128190 | 0.85 | EGFR (0.55) | EGFRBACE1KDM4EMETAP2TDO2 | |
| SCHEMBL31139918 | 0.82 | BACE1 (0.45) | EGFRBACE1KDM4EEPHX2SCN4A | |
| SCHEMBL10280767 | 0.81 | EGFR (0.55) | EGFRPIK3CDPIK3CAFGFR4METAP2 | |
| SCHEMBL20132505 | 0.79 | EGFR (0.51) | EGFRPIK3CDPIK3CAFGFR4TDO2 | |
| SCHEMBL17410801 | 0.75 | EGFR (0.60) | EGFRBACE1PIK3CDPIK3CAKDM4E | |
| SCHEMBL29891394 | 0.75 | EGFR (0.60) | EGFRBACE1PIK3CDPIK3CAKDM4E | |
| SCHEMBL7155460 | 0.74 | NPC1 (0.44) | EGFR | |
| SCHEMBL8644295 | 0.74 | PIK3CA (0.73) | EGFRPIK3CDPIK3CAKDM4EFGFR4 | |
| SCHEMBL25228140 | 0.74 | EGFR (0.54) | EGFRPIK3CDPIK3CAFGFR4TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101568532-A | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL MYERS SQUIBB CO (US) | 2009-10-28 | — | — | CN | disclosed |