Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 2/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK7 | P50613 | 2/20 | 0.34 |
| ▸ | CCNH | P51946 | 2/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13472152 | 0.89 | GRM5 (0.42) | EGFRBTKGRM5CCNCCDK8 | |
| SCHEMBL3651135 | 0.86 | KCNH2 (0.40) | EGFRBTKGRM5CCNCCDK8 | |
| SCHEMBL27785690 | 0.83 | EGFR (0.42) | EGFRBTKGRM5CSNK2A1CCNK | |
| SCHEMBL27785691 | 0.81 | EGFR (0.40) | EGFRBTKGRM5GSK3BCCNK | |
| SCHEMBL3648485 | 0.81 | HRH3 (0.45) | EGFRBTKGRM5CCNCCDK8 | |
| SCHEMBL3643667 | 0.76 | ABL1 (0.41) | EGFRBTKGRM5CSNK2A1CDK2 | |
| SCHEMBL13472157 | 0.75 | GRM5 (0.39) | EGFRBTKGRM5GSK3BDYRK1A | |
| SCHEMBL2328664 | 0.74 | CCNC (0.48) | EGFRBTKCCNCCDK8MKNK2 | |
| SCHEMBL3650318 | 0.74 | CSNK2A1 (0.60) | GRM5GSK3BCSNK2A1GSK3A | |
| SCHEMBL3694294 | 0.73 | EGFR (0.37) | EGFRBTKGRM5GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | claimed |
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | disclosed |