Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.41 |
| ▸ | FLT1 | P17948 | 14/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1347109 | 0.82 | KDR (0.52) | KDRFLT1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1346532 | 0.68 | KDR (0.56) | KDRFLT1KDM4ERAB9A | |
| SCHEMBL1346273 | 0.65 | KDR (0.66) | KDRFLT1 | |
| SCHEMBL1346648 | 0.65 | KDR (0.53) | KDRFLT1 | |
| SCHEMBL6026657 | 0.63 | NPC1 (0.74) | ALDH1A1LMNASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL2385077 | 0.63 | ABCB1 (0.51) | ALDH1A1LMNASMN1; SMN2ABCB1MEN1 | |
| SCHEMBL30887571 | 0.63 | ABCB1 (0.51) | ALDH1A1LMNASMN1; SMN2ABCB1MEN1 | |
| SCHEMBL1346514 | 0.62 | KDR (0.45) | KDRFLT1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27764283 | 0.60 | KDM4E (0.45) | KDRFLT1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL25389540 | 0.59 | NPC1 (0.49) | ALDH1A1LMNASMN1; SMN2KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101600712-A | Novel oxadiazole derivative and thiadiazole derivative having angiogenesis inhibitory activity | SANTEN PHARMACEUTICAL CO LTD (JP) | 2009-12-09 | — | — | CN | claimed |
| CN-103224493-A | Novel oxadiazole derivatives and thiadiazole derivatives having neovascularization inhibitory activity | SANTEN PHARMACEUTICAL CO LTD | 2013-07-31 | — | — | CN | disclosed |
| CN-101600712-A | Novel oxadiazole derivative and thiadiazole derivative having angiogenesis inhibitory activity | SANTEN PHARMACEUTICAL CO LTD (JP) | 2009-12-09 | — | — | CN | disclosed |