Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 12/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | ATRIP | Q8WXE1 | 8/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 7/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27794167 | 0.83 | AURKA (0.40) | ATRPIK3CAMTOR | |
| SCHEMBL2369766 | 0.78 | PDCD1 (0.49) | ATRPIK3CDPIK3CAATRIPPDCD1 | |
| SCHEMBL15805519 | 0.78 | PDCD1 (0.49) | ATRPIK3CDPIK3CAATRIPPDCD1 | |
| SCHEMBL2369761 | 0.78 | PDCD1 (0.49) | ATRPIK3CDPIK3CAATRIPPDCD1 | |
| SCHEMBL20797863 | 0.77 | ATR (0.48) | ATRPIK3CDPIK3CAATRIPPDCD1 | |
| SCHEMBL2513264 | 0.77 | ATR (0.48) | ATRPIK3CDPIK3CAATRIPPDCD1 | |
| SCHEMBL2369785 | 0.76 | PIK3CD (0.57) | ATRPIK3CDPIK3CAATRIPPDCD1 | |
| SCHEMBL20798067 | 0.76 | PDCD1 (0.53) | ATRPIK3CAATRIPPDCD1CD274 | |
| SCHEMBL17748706 | 0.76 | ATR (0.47) | ATRPIK3CDPIK3CAATRIPPDCD1 | |
| SCHEMBL20651554 | 0.76 | PDCD1 (0.53) | ATRPIK3CAATRIPPDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101809002-B | Morpholino pyrimidine derivatives for use in diseases associated with MTOR kinase and/or PI3K | ASTRAZENECA AB | 2013-03-27 | — | — | CN | disclosed |
| CN-101809002-A | Morpholino pyrimidine derivatives for use in diseases associated with MTOR kinase and/or PI3K | ASTRAZENECA AB | 2010-08-18 | — | — | CN | disclosed |
| CN-101541781-A | Morpholino pyrimidine derivatives for the treatment of proliferative diseases | ASTRAZENECA AB (SE) | 2009-09-23 | — | — | CN | disclosed |