Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.66 |
| ▸ | METAP2 | P50579 | 1/20 | 0.66 |
| ▸ | PDE5A | O76074 | 5/20 | 0.60 |
| ▸ | AURKA | O14965 | 7/20 | 0.58 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.53 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170747 | 0.90 | METAP1 (0.72) | METAP1METAP2PDE5AAURKANUDT1 | |
| SCHEMBL1284270 | 0.81 | AURKA (0.73) | METAP1METAP2PDE5AAURKAHPSE | |
| Hydrochloric Acid SCHEMBL11776694 | 0.79 | AURKA (0.71) | METAP1METAP2PDE5AAURKAHPSE | |
| SCHEMBL12833538 | 0.79 | KDM4E (0.68) | METAP1METAP2PDE5AAURKANUDT1 | |
| SCHEMBL11155883 | 0.79 | AURKA (0.67) | METAP1METAP2PDE5AAURKANUDT1 | |
| SCHEMBL9275644 | 0.79 | METAP1 (1.00) | METAP1METAP2PDE5AAURKANUDT1 | |
| SCHEMBL30482943 | 0.79 | METAP1 (1.00) | METAP1METAP2PDE5AAURKANUDT1 | |
| SCHEMBL4048715 | 0.78 | METAP1 (0.58) | METAP1METAP2PDE5AAURKANUDT1 | |
| SCHEMBL11770396 | 0.77 | AURKA (0.70) | METAP1METAP2PDE5AAURKAHPSE | |
| SCHEMBL9269786 | 0.77 | KDM4E (0.64) | METAP1METAP2PDE5AAURKAHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101802013-A | Humanized anti-CD 79B antibodies and immunoconjugates and methods of use | GENENTECH INC | 2010-08-11 | — | — | CN | disclosed |
| CN-101802012-A | anti-CD 79B antibodies and immunoconjugates and methods of use | GENENTECH INC | 2010-08-11 | — | — | CN | disclosed |