Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | GRM5 | P41594 | 5/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544327 | 1.00 | KCNH2 (0.54) | KCNH2GRM5GRM2NPC1MAPT | |
| SCHEMBL1544042 | 0.92 | KCNH2 (0.56) | KCNH2GRM5NPC1MAPTRAB9A | |
| SCHEMBL27810140 | 0.89 | KCNH2 (0.67) | KCNH2GRM5NPC1MAPTRAB9A | |
| SCHEMBL1543750 | 0.89 | KCNH2 (0.46) | KCNH2GRM5NPC1MAPTRAB9A | |
| SCHEMBL1543857 | 0.89 | KCNH2 (0.42) | KCNH2GRM5NPC1RAB9ATP53 | |
| SCHEMBL1544139 | 0.87 | KCNH2 (0.56) | KCNH2GRM5NPC1MAPTRAB9A | |
| SCHEMBL1544376 | 0.87 | KCNH2 (0.52) | KCNH2GRM5NPC1MAPTRAB9A | |
| SCHEMBL27810210 | 0.86 | KCNH2 (0.55) | KCNH2GRM5NPC1MAPTRAB9A | |
| SCHEMBL1544614 | 0.86 | KCNH2 (0.51) | KCNH2GRM5NPC1MAPTRAB9A | |
| SCHEMBL1544101 | 0.85 | KCNH2 (0.52) | KCNH2GRM5NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101723941-A | “1,2,4” oxadiazole as a metabotropic glutamate receptor-5 modulator | ASTRAZENECA AB | 2010-06-09 | — | — | CN | claimed |
| CN-101723941-A | “1,2,4” oxadiazole as a metabotropic glutamate receptor-5 modulator | ASTRAZENECA AB | 2010-06-09 | — | — | CN | disclosed |