Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 14/20 | 0.86 |
| ▸ | AKT2 | P31751 | 9/20 | 0.86 |
| ▸ | AKT3 | Q9Y243 | 9/20 | 0.86 |
| ▸ | PRKCA | P17252 | 3/20 | 0.86 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.86 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.86 |
| ▸ | PRKCB | P05771 | 2/20 | 0.86 |
| ▸ | PRKACA | P17612 | 2/20 | 0.86 |
| ▸ | PRKACB | P22694 | 2/20 | 0.86 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.86 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.86 |
| ▸ | CIT | O14578 | 1/20 | 0.86 |
| ▸ | SGK1 | O00141 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | LATS1 | O95835 | 1/20 | 0.49 |
| ▸ | PRKCG | P05129 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | PRKCH | P24723 | 1/20 | 0.49 |
| ▸ | MARK3 | P27448 | 1/20 | 0.49 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1529676 | 1.00 | AKT1 (0.86) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL15020961 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL187686 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL29360487 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL23858298 | 0.92 | AKT1 (0.98) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL1364223 | 0.92 | AKT1 (0.98) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL29432553 | 0.92 | AKT1 (0.98) | AKT1AKT2AKT3PRKCAROCK1 | |
| SCHEMBL27791781 | 0.91 | AKT1 (0.72) | AKT1AKT2AKT3PRKCAROCK1 | |
| SCHEMBL1529422 | 0.91 | AKT1 (0.72) | AKT1AKT2AKT3PRKCAROCK1 | |
| SCHEMBL1529659 | 0.91 | AKT1 (0.84) | AKT1AKT2AKT3PRKCAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101646427-A | Inhibitors of akt activity | SMITHKLINE BEECHAM CORP US | 2010-02-10 | — | — | CN | claimed |
| CN-101646427-A | Inhibitors of akt activity | SMITHKLINE BEECHAM CORP US | 2010-02-10 | — | — | CN | disclosed |