Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.78 |
| ▸ | MTOR | P42345 | 20/20 | 0.78 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.62 |
| ▸ | ATR | Q13535 | 3/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27773586 | 0.94 | PIK3CA (0.70) | PIK3CAMTOR | |
| SCHEMBL27773574 | 0.93 | PIK3CA (0.67) | PIK3CAMTORPIK3CGATRPIK3CB | |
| SCHEMBL27773610 | 0.93 | PIK3CA (0.80) | PIK3CAMTOR | |
| SCHEMBL27794915 | 0.92 | PIK3CA (0.69) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL27794916 | 0.91 | MTOR (0.69) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL28782200 | 0.91 | PIK3CA (0.68) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL3986179 | 0.90 | PIK3CA (0.86) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL28785175 | 0.90 | PIK3CA (0.79) | PIK3CAMTORPIK3CDPIK3CB | |
| SCHEMBL3987728 | 0.90 | PIK3CA (0.82) | PIK3CAMTORPIK3CGATRPIK3CD | |
| SCHEMBL3984767 | 0.87 | PIK3CA (1.00) | PIK3CAMTORPIK3CGATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101675051-A | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors | WYETH CORP | 2010-03-17 | — | — | CN | disclosed |