Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | GABRP | O00591 | 3/20 | 0.46 |
| ▸ | GABRD | O14764 | 3/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.46 |
| ▸ | GABRE | P78334 | 3/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.46 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.46 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.46 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.42 |
| ▸ | HAT1 | O14929 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778430 | 0.88 | NR4A2 (0.43) | NR4A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2779691 | 0.86 | NR4A2 (0.45) | NR4A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2781901 | 0.85 | NR4A2 (0.41) | NR4A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2780123 | 0.85 | NR4A2 (0.44) | NR4A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL2780111 | 0.82 | NR4A2 (0.48) | NR4A2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL985058 | 0.81 | SLC6A2 (0.53) | PTGDR2NR3C2SIGMAR1 | |
| SCHEMBL983940 | 0.76 | PTGDR2 (0.43) | PTGDR2NR3C2 | |
| SCHEMBL2778867 | 0.71 | NR4A2 (0.49) | NR4A2GABRA1GABRB1GABRA3GABRB2 | |
| SCHEMBL2777419 | 0.69 | NR4A2 (0.49) | NR4A2ACHE | |
| SCHEMBL984732 | 0.69 | SLC6A2 (0.48) | ACHEPTGDR2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257545-A1 | PYRROLIDINYL DERIVATIVES AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009115427-A1 | PYRROLIDINYL DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-24 | — | — | WO | disclosed |