Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 12/20 | 0.66 |
| ▸ | CHUK | O15111 | 11/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802579 | 0.80 | IKBKB (1.00) | IKBKBCHUKPDPK1 | |
| SCHEMBL4689422 | 0.78 | IKBKB (0.97) | IKBKBCHUKPDPK1 | |
| SCHEMBL4685618 | 0.77 | IKBKB (0.74) | IKBKBCHUKPDPK1RIPK1 | |
| SCHEMBL4685346 | 0.77 | IKBKB (1.00) | IKBKBCHUKPDPK1BTKRIPK1 | |
| SCHEMBL4687705 | 0.77 | IKBKB (0.78) | IKBKBCHUKPDPK1ADRB1KEAP1 | |
| SCHEMBL4690245 | 0.76 | IKBKB (0.76) | IKBKBCHUKPDPK1KEAP1RIPK1 | |
| SCHEMBL4686157 | 0.76 | IKBKB (0.76) | IKBKBCHUKPDPK1KEAP1ERN1 | |
| SCHEMBL4687592 | 0.76 | IKBKB (1.00) | IKBKBCHUKPDPK1BTKRIPK1 | |
| SCHEMBL4689165 | 0.76 | IKBKB (0.91) | IKBKBCHUKPDPK1KEAP1 | |
| SCHEMBL4687625 | 0.75 | IKBKB (1.00) | IKBKBCHUKPDPK1ADRB1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101677547-A | Indole carboxamides as the IKK2 inhibitor | SMITHKLINE BEECHAM CORP | 2010-03-24 | — | — | CN | disclosed |