⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28559988 | 0.87 | — | — | |
| SCHEMBL16664836 | 0.85 | — | — | |
| SCHEMBL135186 | 0.85 | — | — | |
| SCHEMBL28195824 | 0.84 | — | — | |
| SCHEMBL6809036 | 0.84 | — | — | |
| SCHEMBL9172199 | 0.84 | — | — | |
| Ammonia Solution, Strong SCHEMBL4579525 | 0.82 | — | — | |
| SCHEMBL5185764 | 0.82 | — | — | |
| SCHEMBL11137753 | 0.82 | FFAR4 (0.35) | — | |
| SCHEMBL11658308 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114560836-A | Preparation method of tetrahydropyran-4-one | 南京焕然生物科技有限公司 | 2022-05-31 | — | — | CN | claimed |
| US-12570625-B2 | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof | NOVARTIS AG (CH) | 2026-03-10 | — | — | US | disclosed |
| CN-112261970-B | 3- (5-Hydroxy-1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and their use in the treatment of IKAROS family zinc finger 2 (IKZF 2) dependent diseases | 诺华股份有限公司 | 2025-02-07 | — | — | CN | disclosed |
| CN-119241499-A | 3- (5-Hydroxy-1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof | 诺华股份有限公司 | 2025-01-03 | — | — | CN | disclosed |
| EP-4306111-A2 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | Novartis AG (CH) | 2024-01-17 | — | — | EP | disclosed |
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |
| US-20230067476-A1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2023-03-02 | — | — | US | disclosed |
| CN-114560836-A | Preparation method of tetrahydropyran-4-one | 南京焕然生物科技有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-114560836-A | Preparation method of tetrahydropyran-4-one | 南京焕然生物科技有限公司 | 2022-05-31 | — | — | CN | disclosed |
| US-20110071126-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. | 2011-03-24 | — | — | US | disclosed |
| US-20110071126-A1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. | 2011-03-24 | — | — | US | disclosed |
| WO-2010105179-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010105179-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| EP-0982305-B1 | Indane-1-ol derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-03-06 | — | — | EP | disclosed |
| US-6153625-A | Indan-1-ol compounds | ADIR ET COMPAGNIE (FR) | 2000-11-28 | — | — | US | disclosed |
| EP-0982305-A1 | Indane-1-ol derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-03-01 | — | — | EP | disclosed |
| US-5625046-A | Hydroxyl projecting groups for organic synthesis | KING'S COLLEGE LONDON (GB) | 1997-04-29 | — | — | US | disclosed |
| US-5436331-A | Etherification with N-aryl-4-alkoxy-1,2,5,6-tetrahydropyidine | KINGS COLLEGE LONDON (GB) | 1995-07-25 | — | — | US | disclosed |
| EP-0298982-B1 | PROTECTING GROUPS FOR ORGANIC SYNTHESIS | KING'S COLLEGE LONDON (GB) | 1991-08-28 | — | — | EP | disclosed |