Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473344 | 0.86 | AKT1 (0.41) | AKT1RPS6KB1KITMEN1KMT2A | |
| SCHEMBL473359 | 0.86 | AKT1 (0.41) | AKT1RPS6KB1KITMEN1KMT2A | |
| SCHEMBL473424 | 0.85 | AKT1 (0.42) | AKT1RPS6KB1 | |
| SCHEMBL473311 | 0.81 | MEN1 (0.50) | AKT1RPS6KB1MEN1KMT2AALDH1A1 | |
| SCHEMBL473312 | 0.79 | AKT1 (0.37) | AKT1RPS6KB1MEN1KMT2A | |
| SCHEMBL10159411 | 0.79 | AKT1 (0.37) | AKT1RPS6KB1KITMEN1KMT2A | |
| SCHEMBL27802512 | 0.78 | RPS6KB1 (0.41) | AKT1RPS6KB1 | |
| SCHEMBL473308 | 0.77 | AKT1 (0.46) | AKT1RPS6KB1 | |
| SCHEMBL1790785 | 0.76 | RPS6KB1 (0.47) | AKT1RPS6KB1MEN1KMT2AALDH1A1 | |
| SCHEMBL473341 | 0.74 | PDE10A (0.45) | AKT1RPS6KB1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101959516-A | Combination therapy comprising quinoxaline PI3K alpha inhibitors for the treatment of cancer | EXELIXIS INC | 2011-01-26 | — | — | CN | disclosed |