Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15317986 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2LTA4HEPHX1EPHX2RECQL | |
| SCHEMBL27348781 | 0.89 | SMN1; SMN2 (0.58) | SMN1; SMN2LTA4HEPHX1EPHX2RECQL | |
| SCHEMBL8280843 | 0.84 | CA1 (0.47) | SMN1; SMN2LTA4HEPHX1EPHX2RECQL | |
| SCHEMBL8280869 | 0.84 | CA1 (0.47) | SMN1; SMN2LTA4HEPHX1EPHX2RECQL | |
| SCHEMBL13739085 | 0.84 | EPHX1 (0.44) | SMN1; SMN2EPHX1EPHX2RECQLKDM4E | |
| SCHEMBL13738686 | 0.84 | EPHX1 (0.44) | SMN1; SMN2EPHX1EPHX2RECQLKDM4E | |
| SCHEMBL13738688 | 0.84 | EPHX1 (0.44) | SMN1; SMN2EPHX1EPHX2RECQLKDM4E | |
| SCHEMBL8280845 | 0.84 | CA1 (0.47) | SMN1; SMN2LTA4HEPHX1EPHX2RECQL | |
| SCHEMBL2780287 | 0.82 | EPHX1 (0.43) | SMN1; SMN2EPHX1EPHX2RECQLKDM4E | |
| SCHEMBL27359807 | 0.82 | EPHX1 (0.43) | SMN1; SMN2EPHX1EPHX2RECQLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795256-B2 | Thieno-pyridinone derivatives as kinase inhibitors | UCB PHARMA S.A. (BE) | 2010-09-14 | — | — | US | disclosed |
| US-20070078131-A1 | Thieno-pyridinone derivatives as kinase inhibitors | CELLTECH R&D LIMITED (GB) | 2007-04-05 | — | — | US | disclosed |
| EP-1680429-A1 | THIENO-PYRIDINONE DERIVATIVES AS KINASE INHIBITORS | Celltech R & D Limited (GB) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005042540-A1 | THIENO-PYRIDINONE DERIVATIVES AS KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078131-A1 | Thieno-pyridinone derivatives as kinase inhibitors | MAP3K6, MAP4K2, MAP3K15 | SMN1; SMN2 3314/4885LTA4H 1643/4885EPHX1 1047/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.