Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27824888 | 0.89 | RPS6KA3 (0.45) | RPS6KA3JAK2BRD4 | |
| SCHEMBL27824865 | 0.86 | RPS6KA3 (0.44) | RPS6KA3JAK2BRD4 | |
| SCHEMBL28786504 | 0.83 | RPS6KA3 (0.40) | RPS6KA3JAK2BRD4 | |
| SCHEMBL28790440 | 0.78 | STAT6 (0.49) | RPS6KA3JAK2BRD4 | |
| SCHEMBL27803985 | 0.77 | RPS6KA3 (0.56) | RPS6KA3JAK2BRD4 | |
| SCHEMBL27804078 | 0.77 | JAK2 (0.43) | RPS6KA3JAK2BRD4 | |
| SCHEMBL28790311 | 0.75 | JAK2 (0.44) | JAK2BRD4 | |
| SCHEMBL1655623 | 0.74 | RPS6KA3 (0.50) | RPS6KA3JAK2BRD4 | |
| SCHEMBL27803977 | 0.73 | JAK2 (0.47) | JAK2BRD4 | |
| SCHEMBL27804170 | 0.72 | JAK2 (0.46) | JAK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981036-A | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2011-02-23 | — | — | CN | claimed |